FSL0593

Structure

• InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
• InChIKey=DDUHZTYCFQRHIY-RBHXEPJQSA-N

Synonyms

• 126-07-8
• 7- Chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'-methylcyclohex- 2'-en-3'-one)
• Amudane
• Anualane
• Anujane
• Curling Factor
• Fulvicin
• Gricin
• Grifulvin
• Grisactin
• Griseofulvin
• Grisovin
• NSC-34533

Origin

Penicillium griseofulvum

Biological activities

Inhibition of mitosis

Therapeutic

Antifungal

Target

Tubulin
Keratin

Assay information

Growth inhibition against Botrytis allii (25 μg/dish), Botrytis Cinirea (25 μg/dish), A. fumigatus (250 μg/ml), A. niger (5 μg/ml), A. clavatus (5 μg/ml), C. albicans (5 μg/ml)
Apoptosis induction in human cancer cells, HT29 (10 μM), COLO205 (10 μM), HepG2 (50 μM), Hep3B (20 μM), and HL60 (20 μM)